基正交设计结合FAHP-熵权法-独立性权法优化沈氏通络方提取工艺

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【关键词】沈氏通络方；正交实验；模糊层次分析法；毛蕊异黄酮葡萄糖苷；柚皮苷；指纹图谱相似度【中图分类号】R284.2 【文献标志码】A 【文章编号】1007-8517（2026）03-0039-08DOI：10.3969/j. issn. 1007-8517. 2026. 03. zgmzmjyyzz202603009

Optimizationof Extraction Processfor Shenshi Tongluo Formula Based on Orthogonal Design ombined with Fuzzy Analytic Hierarchy Process，Entropy Method and Independent Weight Metho（

TAN Mei'e1PAYIMAN ⋅ Haimiti1LI Qian2*YU Ning1 1. Xinjiang Uygur Autonomous Region Institute of Materia Medica， Xinjiang Uyghur Pharmaceutical Laboratory，Urumqi 83OO11，China; 2.Hospital of Chinese Medicine Afliated to Xinjiang Medical University，Xinjiang KeyLaboratory of Processingand Research of Traditional ChineseMedicine，Urumqi 83OoOO，China

Abstract：ObjectiveTooptimizetheextractionprocessofShenshiTongluoformulausingorthogonal experimentaldesigncombined withfuyanalytichierarchyprocess，entropyweightandindependenceweightMethodsTecontentofCalycosin7glucosidendnaringin，extractionamountandsilarityoffingerpritsastekyevaluationindexesTeextractiontimes，extractiontieadtheamountof waterweretakensteinvestigationfactors，thediferentlevelsofachfactorweredeterindbysinglefactortestFuzyanlytichierarchprocss，ntropyweightmetodandindependenceweghtmethodwereusedtodetermineteweightcoeficientofeachndex.Thecomprehensivescoreoforthogonaldesignresultswascalculated，andtheoptimalextractionprocess parametersof Shenshi Tongluo formulareseledandverifedResultsTeweightcoeficientofachindexwereasfollws：theweightoftecontentofCalycosin -7- glucoside and naringin were 33% and 42% ，the weight of paste yield was 22% ，and the weight of fingerprint similarity was 3% .The optimal extraction process was determined to add 6 times water and extract 2 times for 1，0 hours each time. Conclusion The optimizedextractionparametersofShenshiTongluoformulawerestableandfeasible，whichprovidedareferenceforthedevelopmentof otherwater extraction formulas and provideda theoretical basis for the folow-upresearch of Shenshi Tongluo formula.

KeyWords：ShenshiTongluoFormula；Orthogonal Experiment;；FuzzyAnalyticHierarchyProcess；Calycosin-7-glucoside Naringin；Fingerprint Similarity

腰椎退行性病变，亦称退行性脊柱炎、脊柱退行性关节炎，是一种随着年龄增长而逐步显现的腰椎组织结构自然老化及功能减退性病变[1-3]。（剩余9854字）