基于网络药理学探讨姜黄素干预肾损伤的分子机制

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中图分类号 R285.5

文献标志码 A

文章编号 1007-7731(2026)08-0084-04

DOI号 10.16377/j.cnki.issn1007-7731.2026.08.020

Exploring the molecular mechanism of curcumin in intervening renal injury based on network pharmacology

Bi Yuqing Kong Xinyue Feng Rui Qu Lingzhi Liu Tianxiang Du Li Wu Kaiwen Gao Xiaoli He Ying (Department of Biology and Food Engineering, Lyuliang University, Lyuliang , China)

Abstract Curcumin is a natural polyphenol extracted from Curcuma longa of the Zingiberaceae family. It can be used as a feed additive and has been widely applied in livestock and poultry breeding. To explore the molecular mechanism of curcumin in intervening renal injury, potential targets of curcumin were identified via network pharmacology based on data from databases including TCMSP, PubChem, and SwissTargetPrediction. Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were subsequently performed on the intersecting targets. The results revealed 64 potential therapeutic targets of curcumin and 5 815 renal injury-related targets, among which 55 core intersecting targets were obtained. GO enrichment indicated that these targets were mainly involved in biological processes such as the regulation of cell proliferation and apoptosis; cellular components including nuclear structure and membrane systems; and molecular functions related to core kinase activity and specific signal transduction. KEGG pathway enrichment demonstrated that the core targets were predominantly enriched in cancer-specific pathways such as pancreatic cancer and colorectal cancer, signal transduction networks including the HIF-1 and PI3K-Akt pathways, as well as inflammation-related pathways such as the PD-L1/PD-1 immune checkpoint pathway. Comprehensive analysis suggested that curcumin may exert a protective effect against renal injury by regulating multiple signaling pathways including HIF-1 and PI3K-Akt, thereby inhibiting inflammatory responses and alleviating oxidative damage, reflecting the characteristic multi-target and multi-pathway synergistic intervention. This study provides a reference for the further development and utilization of curcumin

resources.

Keywords curcumin; renal injury; network pharmacology; resource utilization

姜黄素是从姜科植物姜黄中提取的天然多酚类化合物，是姜黄发挥药理作用的主要活性成分[1-2]。（剩余6409字）