藏药二十五味珊瑚丸对血脑屏障作用及机制研究

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【关键词】二十五味珊瑚丸；血脑屏障；Claudin-5；E－cadherin；ABCB1；ABCC1

【中图分类号】R285.5 【文献标志码】A 【文章编号】1007－8517（2026）04-0033-08

DOI：10. 3969/j. issn. 1007 -8517. 2026. 04. zgmzmjyyzz202604007

StudyontheEffectandMechanismof ZangMedicine Ershiwu FlavorsShanhu Pillsonthe Blood-BrainBarrier

WANG Shuo SHU Junzhe YUAN YujiangXIAO ShuqiXIE Hongjun* Medicine collegeof XizangUniversity，Lhasa 85Oooo，China

Abstract：ObjectieToevaluatetheefectsofdiferentpolarityextractsofErshuFlavors ShanuPillontheblood-brainbarrier（BBB）bothinvivoandinvitro，andelucidatetheunderlying mechanisms.MethodsBBBpenetrationefectsoftheextractswere investigatedusing invivoandinvitroBBBmodels，whileELISAkitswereemployedtoexplorethemechanisms.Results Thesteam distlltionfractionexiedtestrongestehancementofBBpermeabilityandsigcantlydowegulatedteexpresionofCudin -5 ，E-cadherin，ABCB1，andABCC1.ConclusionErshiwuFlavors ShanhuPilsmayenhanceBBBpermeabilitybyinhibitingthe MAPK-related signaling pathway through its active components，thereby regulating the expression of Claudin -5 ，E -cadherin，ABCB1，and ABCC1. This mechanism improves the structural integrityof the BBB and reduces drug efflux.

Key Words：Ershiwu Flavors Shanhu Pills；Blood-brain Barrier；Claudin-5；E-cadherin；ABCB1；ABCC1

血脑屏障（bloodbrainbarrier，BBB）由内皮单层细胞、星形胶质细胞和周皮细胞组成，能够阻止绝大多数外源性物质透过，并选择性地将脑内有害物质或过剩物质泵出脑外，维持脑内微环境的稳定。（剩余10834字）