基于兴奋性氨基酸细胞毒性作用与中医“浊毒”理论探讨血管性痴呆的病机

【中图分类号】R259 【文献标志码】A 【文章编号】1007-8517（2026）04-0027-06

DOI：10.3969/j. issn. 1007 -8517. 2026. 04. zgmzmjyyzz202604006

Exploring the Pathogenesis of Vascular Dementia Based on the Cytotoxic Effect of Excitatory Amino Acidsandthe“TurbidToxin”Theoryin Traditional ChineseMedicine

ZHOU Yuanyuan’WANG Enlong2* 1.Liaoning University of Traditional Chinese Medicine，Shenyang 11O847，China; 2.First Afiliated Hospital of Liaoning Universityof Traditional Chinese Medicine，Shenyang 11Oooo，China

Abstract：Vasculardementia（VaD）isacommonneurodegenerativeclinicalsyndromecausedbycerebrovasculardiseases，characterizedbypathologicalchangessuchasbraintisuedamageandlocalizedcerebralbloodflowalterations，ultimatelyleadingtoem ryandcognitiedysfunction.AkeymechanismunderlyingtheonsetandprogresionofVaDivolves excitotoxicitymediatedbyNMDA receptors，whichrednselyisrbutedinteippcampalCAreginofthebrainDuringacutecerebralischemiaxcesieeleae of excitatoryaminoacidsactivatesNDAreceptors，trigeringcalciumoverloadandsubsequentnuroaldeathNotablythecyotoxic efectsinducdbyerebraliscemiaypoiasresimlariswithteoreconeptof“toxibstrutionofcollterals”ieTurbid ToxinTheoryof TraditionalChinese Medicine（TCM）．Therefore，theTurbidToxinTheorycanberegardedasakeypathological frameworkforVaD.Therapeutically，applying turbidtoxin-resolvinganddetoxifying methodstoinhibit excitatoryaminoacid－induced cellular damage is critical for improving cognitive function and daily living abilities in VaD patients.

KeyWords：Vascular Dementia；Excitotoxicity； Turbid Toxin Theory；Resolving Turbid Toxins and Detoxifying

血管性痴呆（vasculardementia，VaD）是一种常见的神经退行性疾病，是各种脑血管疾病引起脑组织损伤、局部脑血流的改变等各种病理变化，进而导致的认知功能障碍综合征[1]。（剩余12777字）