基于“脾藏营舍意”探讨“微生物－肠－脑轴”与帕金森病抑郁的相关性

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【中图分类号】R259 【文献标志码】A 【文章编号】1007－8517（2026）04-0016-06

Abstract：Asacorenon-motorsymptomof Parkinson’s disease，depresion inParkinson'sdisease，whose pathologicalmehanismisnotyetclear，seriouslyectsthequalityoflifeofpatints.Researchhasrevealedthatthereisacomplexassociationbetwen the“microbe－gut-brainaxis”andthecentralnervoussystem，andthatintestinalfloracaninfluencethedevelopmentofdepresion inParkinson’sdiseasethroughtwo-waycommunicationbetwenthegutandthebrain.AccordingtothetheoryofChinesemedicine， "spleenstoringnutrientandhousingidea”，“theideaofthespleen”isbasedon“thenutrint”，whichiscloselyrelatedtotemental andspiritualactivitesofthebodyTherefore，thedeficiencyofthespleenandthelackofinteralcontrolofthemindmaybethecore mechanismofPrkinson’sdiseasedepresion.Atthesametime，spleendeficiencywilleadtointestinalfloraimbalance.Trefor， thispapertakestheteoryof“spleenstoringnutrientandhousingideaasaguide，basedotheisticperspectiveofspentes tines-brain，andanalyzesthephysiologicalcharacteristicsandfunctionsoftesplnfromtheinteractionbetweethespleenand stomachandintestialmcroorganss，toexploreitscorelationithteoccurrenenddevelopntofParkisn’sdisase，adto provideanopprtunityforthetreatmentofdepressoninParkinson’sdiseasebasedontheteoyofthespleenandstomachThiswil provideascientificbasisfortheinovationofChinesemedicinetreatmentbasedontheteoryofspleenandstomachinthetreatmentf depression in Parkinson's disease.

Keywords：Parkinson’sDisease；Depresion；SpleenStoring Nutrientand Housing Idea；Microbiota－gut-BrainAxis; Gut Microbiota

帕金森病（parkinson'sdisease，PD）是一种累及中枢神经系统、肠神经系统、自主神经系统及免疫系统的多灶性神经退行性疾病[1]，以黑质多巴胺能神经元死亡及 ∝ -突触核蛋白（ ∝ -synucle-in， ）聚集组成的路易小体为特征性病理标志[2]。（剩余11838字）