基于“气虚痰结络瘀”探讨肺纤维化病机演变与辨治思路

[关键词]肺纤维化；气虚痰结络瘀；“虚-滞-损”；演变规律；辨治思路 [中图分类号]R256 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2026.01.018

[Abstract]Pulmonaryfibrosis（PF）isachronicprogresiveinterstitiallungdiseaseforwhichontemporarybiomedicinetll haslimitationstohaltdiseaseprogressionorreverselung functionimpairment.BasedontheChinesemedicinetheoryof"qi deficiencywithplegmretentionandcolateralstasis"，ourteaminnovativelyproposesthatPForiginatesfromthedeficiencyfthe spleen，lng，andkidneyastherootcause，withintertwinedphlegm，bloodstasisandtoxinaccumulationasthemechanismof progression，andungcolateralstasisandimpaimentastheunderlyingfactorofthechronicintractabilityItunfoldsthougha dynamicevolutionof"deficiencyretention-impairment"Inacordancewiththetherapeuticprincipleof"treatingboththetipand rot，reinforcinghalthyiandremovingpathogenicfactorssimultaneously"，asystematictherapeuticstrategyhaseendevelopd： tonifyingthesplen，andbenefitingthelung，fortifyingthekidneyandtheYuan-primordialqitoreinforcehealthyqiand strengthentheody;limnatingplegmxpllingstasis，movingtoxisanddispeingmasestoliminaepathogenicctosad unblockstagnation;sothingqiandblood，andregulatingandtonifingthelungandidneytoharmonizemeridiansandfaciliate restoration.This framework aims toprovideanewperspectiveonthepathogenesisanalysisandanovel clinicalapproach for Chinese medicine intervention in PF.

[Keywords]pulmonaryfibrosis;qideficiencywithphlegmretentionandcolateralstasis；"deficiency-retention-impairment";evolution pattern; pattern-based treatment strategy

肺纤维化是一种慢性、进行性的纤维化性间质性肺疾病，其发病风险与年龄和性别密切相关，在老年男性群体中尤为常见I。（剩余7148字）