水体中泼尼松龙暴露对斑马鱼胚胎发育的影响

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中图分类号：X171.5 文献标识码：A 文章编号：1006-060X（2026）01-0081-06

Abstract：Thewidespreaddischargeevironmentalhomonespossaseriousthreattoaquaticrganisms.Inthisstdyebafish embryoswereusedasamodeltoexplore tetoxicefect68-hcuteexposure toprednisoloeatdiferentconcetratios（o，50， and 500ng/L ）onthe embryonic development zebrafish.Theresults showedthatcompared with the control group，aqueous exposure to 5ng/L prednisolone promoted the autonomous movement zebrafish embryos （increasing the number movements within 30s increases by 8 times） and improved the hatching rate by 15.27% . Exposure to prednisolone at 50 and 500ng/L significantly decreased the heart rate zebrafish embryos by 10.81% and 14.23% ，respectively， compared with the control group at the time point 72h Exposure to prednisolone at 500ng/L led to motor sluggishness （decreasing the average swimming speed by 29.69% compared with thecontrolgroup）andinducedembryonicevelopentalfomatios（soliosis）.Iditionxposuretprednisoloeat5d ng/L increasedthe mortalityratezebrafsh embryosby48.60and40.26percentagepoints，respectivelycompared withthecontrol group.Thedata showedthatlowconcentrations prednisolone hadpromoting efectontheembryonicdevelopmentzebrafish， while 50-500ng/L prednisolone induced irreversible toxic effect.The results provided an important basis for assessing the aquatic ecological risk environmental hormones.

Key words：environmental hormones; prednisolone; zebrafish embryos; exposure to toxin

环境激素（EnvironmentalHormone）又称环境内分泌干扰物（Endocrine DisruptingChemicals，EDCs）或环境荷尔蒙，是一种天然存在于环境中的或污染环境的化合物，它能模仿并发挥生物体内激素的生理生化功能，并对生物的生长、发育、繁殖、运动等生命活动产生显著的影响[1-3]。（剩余9714字）