基于网络药理学与分子对接技术预测止颤灵颗粒对帕金森病的作用机制
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中图分类号：R742 文献标识码：A文章编号：1006-1959（2026）03-0028-07
DOI：10.3969/j.issn.1006-1959.2026.03.005
Predictionof theMechanismof Zhichanling Granules on Parkinson'sDisease Based on Network Pharmacology and Molecular Docking Technology
WUJincan’，LIShiju，WANGYanxu3，PANXiaoming²，CHENXinyi’，LIANGRuixin1，HUANGDing4 （1.The Second Clinical College of Fujian Universityof Chinese Medicine，Fuzhou ，Fujian， China; 2.Departmentof Neurology，the Second People's Hospital Afiliatedto Fujian Universityof Chinese Medicine，Fuzhou 350003，Fujian，China;3.Departmentofurologyatedole'sospitalofanUvesityfseicine，Fzou，u; 4.TheFirstClinical MedicalCollge，FujianUniversityofChinese Medicine，Fuzhou 35o122，Fujian，China）
Abstract：ObjectieTopredicthemechanismofZichalinggranulesonarkinson'sdisease（D）basedonnetworkpharmacologndmoleular dockingtechologyMethodsTeactiveingredientsandtargetsofZhichanlinggrauleseresreeedandpredictedtroughtheTCMsyste pharmacologydatabaseandanalysisplatforandHerbdatabase.ThetargetofPDwassrenedusinghumanGeneCardsVenny2.1wasusedto drawVenndiagamtobtainhtesetioargetofteioalCieicieopodndcosaoftaeausedto constructheintersetionnetworkandproteininteractionnetworkdagamofCinesemedicineactiveingreientsandtargetespectivelye intersectiontargetswereerichdygeneontoloy（GO）andKyotoEncylopediaofGenesandGenoes（KEGG）andtheeyoreagetsee screnedbyutoDoksofaresedtoefooleulaingetweetiedentsndaesofterugtoifte bindingactivitsulotofiecitsdsfdd ori inteoaefoingtaateOialctodastoalo estrogenrceptoosposiliaaltbuiteptiddhoeporaaessulsfalst genesereldaloospe tyrosinephosporylatioandprotentophosporylatioKGGichentaalysissowdthattjoralingpathwasoledliidd tosei targetswere：osinekinase，eatsokproteinOlignalrasductionfactorandtraseriptioalactivatorumantenepto phosphoiosiol-aeatalbitelaetidleulaingfiodatoetdogli mainactiveingedousioZlingalesateouhroslerosisdcthass therapeutic characteristicsof "multi-component，multi-targetand multi-pathway"of this TCMcompound.
KeyWords：Parkinson's disease; Zhichanling granules;Network pharmacology；Molecular docking
帕金森病（Parkinson'sdisease，PD）是一组伴有帕金森病样运动问题的神经系统退行性疾病，临床以肢体僵硬、动作缓慢、姿势步态障碍和静止性震颤为主要表现I。（剩余7577字）
