骨肉瘤转移与上皮－间质转化靶基因及小分子化合物预测

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中图分类号：R738.1 文献标识码：A文章编号：1006-1959（2026）03-0001-08

DOI：0.969/j.issn.006-959.06.0.00

Osteosarcoma Metastasis and Epithelial-mesenchymal Transition Target Genes andSmallMoleculeCompoundsPrediction

PANRui1，MADan²，ZHANGChuanlin³，LIMei4，ZENGYaling1，LIUJianping² （1.Department of Nutrition，People'sHospital of Yuxi City，Yuxi 6531O0，Yunnan，China; 2.DepartmentofScientificResearchMnagement，People'sHospitalofYuxiCityYuxi6531Oo，Yunnan，hna; 3.DepartmentofBone Surgery，People'sHospitalofYuxiCity，Yuxi 6531Oo，Yunnan，China; 4.Department of Emergency Surgery，No.2People's Hospital of Yuxi City，Yuxi 6531O0，Yunnan，China）

Abstract：Oeiltitsf providearesearchbasisfortheacuratepredictionandtreatmentofosteosarcomametastasisMethodsTheosteosarcoma-relatedgenesetwas dowloadedfroteublictabsendieretialgealsasfodusinRfaeiglepesedsy WGCNA，andeteseiosniheilealasiogesetGndKGGcalicealyiss performedontheintersectiongenesndtheemacinelearigmethodsereusedtoetemietecoregenesandtheOCureanda wereusedtopredictthevaluofthoegenesTeaipathwasofregeneseredeteinedbysinglegenSEArichentaasnal theDSigDBdatabsesedtcthalluleopodsofegeealloleulepodsio werescrendutsulsfelaled4oosillelsis clustering5oiial combined.TwocoregenesCXCL16ndFH2werescrenedythreeindsofmachinelearing.TefirstfivepathwaswereobtainedbyEA enrichmentanalysisofsinglegene，whichweremainlyenichedinimmunityandatigenDigDBpredicedthatthefrstfivealloleule compoundserU，roosadsctedok

ConclusionCC6ndFgeneexpeedtodsagetkersfoteosacoaetastasisovidingaela basis for drug development.

KeyWords：Epithelial-mesenchymal transition;Osteosarcoma; Bioinformatics;Smallmoleculecompounds

骨肉瘤（osteosarcoma，OS）是一种起源于骨骼间叶组织的原发性恶性肿瘤，以能产生骨样组织的瘤细胞直接形成骨样组织或骨质为特征，是最常见的骨恶性肿瘤之一，发病年龄呈双峰分布，10～19岁和65岁以上老年人群占所有原发性骨恶性肿瘤的 1/5[1，2] 。（剩余9781字）