黄毛惚木及其组方体外抗氧化和降血糖活性研究

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【中图分类号】R285.5 【文献标志码】A 【文章编号】1007-8517（2026）05-0046-05

DOI： 10.3969/j .issn.1007-8517.2026. 05. zgmzmjyyzz202603010

StudyontheInVitroEvaluationofAntioxidantandAnti-DiabeticPotential ofAraliachinensisL.and ItsPrescriptions

IU Jianmei1LIAO Yunting²ZHUANG Yuanbei²ZHANG ShengyuanPENG Jingsong² ZHU Xinhao² CEN Meixiu1

1.Meizhou Hospital of Guangzhou Universityof Chinese Medicine（Meizhou Hospital of Traditional Chinese Medicine， Meizhou Tianjiabing Hospital，Meizhou Academy of Chinese Medical Sciences），Meizhou 514071，China; 2.Medical College，Jiaying University，Meizhou 514031，China

Abstract：ObjectiveToinvestigatetheinvitroantioxidantand hypoglycemicactivitiesof AraliachinensisL.rotand itsprescription，providingascientificbasis fortheirpotentialapplicationinfunctional foodsordrug development.Methods The 75% ethanolextractsofraliachinensisLrotanditsprescriptiowereobainedusingulrasound-asistedextractionTetotalsapoincontentwasdeterminedbythevanilin-perchloricacidmethod.AntioxidantactivitywasevaluatedusingDPPHandABTSradicalcavenging assays，while hypoglycemic activity was assessed via α - glucosidase inhibition experiments. Results The total saponin content of Aralia chinensis L. root reached 25.64mg/g .The root extract exhibited significant antioxidant capacity，with enhanced activity observed in prescription ① （Aralia chinensis L. + Senna tora（L.）Roxb.）and prescription ② （Aralia chinensis L. + Euphorbia humifusa W.）． Prescription ② demonstrated strong antioxidant effects （ 1C50 values for DPPH and ABTS radical scavenging were 29.46 and 1.54mg/mL ，respectively）. In hypoglycemic tests，prescription ② showed synergistic effects，with α - glucosidase inhibitory activity （ lC50=0.38mg/mL ）surpassing that of acarbose（ 1C50=0.42mg/mL ）.Enzyme kinetic analysis indicated that prescription ② irreversiblyinhibited α - glucosidase. Conclusion Prescription ② exhibits significant in vitro antioxidant and hypoglycemic effects， makingitapromisingandidateforfurtherdevelopmentasanaturalantioxidantorhypoglycemicfunctionalingredient.Thesefindings providetheoreticalsupportforotiizing rditioalChinesemedicineompoundfoulatiosndteirotentalaplicatinindbetes adjuvant therapy.

Keywords：Aralia chinensisL.；Antioxidant；Hypoglycemic； α -glucosidase；Traditional Chinese Medicine Formulation

近年来，随着人们健康意识的提升，天然植物活性成分因其低毒副作用和多靶点作用特点，在抗氧化与降血糖领域受到广泛关注。（剩余8537字）