三白颗粒的制备工艺研究

打开文本图片集

【中图分类号】R284.2 【文献标志码】A 【文章编号】1007-8517（2026）05-0036-06

DOI：10. 3969/j. issn.1007-8517.2026. 05. zgmzmjyyzz202603008

ThePreparation Technologyof Sanbai Granules

LI Qian1YANG Long²YANG Yan³TAN Shuwen³CHEN Lingyun4ZHANG Shuangyan4FANG Qixian1 1.College of Agronomyand Horticultural Technology，Yunnan Vocational and Technical Collge ofAgriculture，Kunming

650212，China；2.Development PlanningOffce，YunnanVocationaland TechnicalCollegeofAgriculture，Kunming 650212，

China;3.CollgeofFod，Pharmaceuticaland Great Health，Yunan Vocationaland Technical Collgeof Agriculture，Kunming 650212，China；4.Collge of Chinese Materia Medica，Yunnan Universityof Chinese Medicine，Kunming 650500，China

Abstract：Objective Tooptimizethepreparation technologyof Sanbai Granules，including extraction，concentration，drying， andgranulatioprocese.MethodsTheextractioproessasoptimizedbyorthogonal experimentaldesignusing extractiontie，watervolume，andextractionfrequencyasiuencingfactors.Thtransferateofpaeonflorinandtheyieldofdryextractwereeployed ascomprehensiveevaluationindices.Theefectsofwetingagentconcentration，typeandamountofexcipientsonthegranulation process were also investigated. Results The regression equation for paeoniflorin in the extract was γ=1410.5x+588.34 （ R2=0.999 3），with an average recovery of 98.24% 三 RSD=1.09%，n=6 ）.The optimal extraction conditions were as follows：decoction with 8timestheamountofwaterxtractedhreetimes，eachfor1.5hours.Drygranulationwasselectedasthepreferredmethod.Teoptimal formulation consisted of dry extract powder and dextrin at a ratio of ，with 82. 5% ethanol as the weting agent，resulting in satisfactorygranuleformation.ConclusionTheoptimizedpreparationprocessisstable，feasibleandreproducible，providingareference for the industrial production of Sanbai Granules.

KeyWords：Sanbai Granules；Preparation Technology；Orthogonal Design；Dry Granulation

三白颗粒为立项研发的中药制剂，目前处于工艺研究与优化阶段，其组成为由白芍、白术、茯苓、甘草4味中药。（剩余7047字）