基于阴阳理论探讨线粒体稳态与多囊卵巢综合征的关系及治疗

【中图分类号】R271.9 【文献标志码】A 【文章编号】1007-8517（2026）05-0020-05

DOI： 10. 3969/j. issn. 1007 - 8517. 2026. 05. zgmzmjyyzz202603005

ExplorationontheRelationshipBetweenMitochondrial HomeostasisandPolycystic Ovary Syndrome and Its Treatment Based on the Yin- Yang Theory

SONG Shunji1ZHANG Yang² 1.Liaoning University of Traditional Chinese Medicine，Shenyang 11O847，China; 2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110847，China

Abstract：Polycysticovarysyndrome（PCOS）isacomplexendocrinedisorder，andmitochondrial homeostasisimbalanceisone f itspathologicalmechanisms.ThispaperexpoundsthepathologicalmechanismofPCOSfromtheperspectivesofthetheoryofYinand YangintraditionalChinesemedicine（TCM）andmitochondrialhomeostasis.FromtheTCMperspective，PCOSisasydromeofdeficiencyinoriginandexcessinsuperficiality，withthebasicpatogenesisof“YangdeficiencyndYiexcess.Astheenergfactoryof cels，mitochondrialdysfunctionisassociatedwithavarietyofdiseases.InTCMtheoryYinYangimbalanceisthefundamental causeofdiseases.Inhibitionofmitochondrialbiogenesis，dynamicdisorders，autophagydisturbanceandotherabnormalitiescanbere gardedasthereflectionofYn-Yangimbalanceat thecelularmicrolevel.Thesedisordersafectthstructueandfunctionofmito chondria，therebyinterfering withenergymetabolismandleading toYin-Yang imbalance.Therefore，basedontheTCMYin-Yang theory，taking“strengtheningYangandsuppesingYin”asthbasicterapeuticmethodtogulateiochondialhomeostasisisof crucial significance for the prevention and treatment of PCOS.

KeyWords：Mitochondria；Obesity；MitochondrialHomeostasis；Traditional Chinese Medicine；PolycysticOvarySyndrome

多囊卵巢综合征（polycystic ovarysyndrome，PCOS）是育龄期妇女常见的内分泌疾病，以月经不调、高雄激素血症（hyperandrogenism，HA）以及胰岛素抵抗（insulinresistance，IR）为主要临床特征[1]。（剩余11002字）