土王赶毒润喉方对急性咽炎模型大鼠的抗炎作用研究

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【中图分类号】R285 【文献标志码】A 【文章编号】1007-8517（2026）05-0025-05

DOI：10.3969/j. issn.1007-8517. 2026. 05. zgmzmjyyzz202603006

The Anti -inflammatory Effect of Acute Pharyngitis

LIU Chunyan1NIU Jianjun1CHAI Yihui²WU Wei1WEN Qinqin1ZENG Fanyong'YAN Chaocao1* 1.Dejiang County Hospital of Ethnic Traditional Chinese Medicine，Tujia Instituteof Medicine，Dejiang 5652Oo，China; 2.Guizhou Universityof Traditional Chinese Medicine，School of Basic Medicine，Guiyang 550oo，China

Abstract：Objective Toexploretheeficacyandanti-inflammatorymechanismofacutepharyngitisinratsandprovideabasis forclinicalapplication.MethodsTheexperimentweredividedintocontrol group，model group，positivedruggroupO.9g／（kg·d）]，and high，medium and low doses of water extract [5.2g/Ω（kg⋅d） ，2.6g/（kg·d），1.3 g/（kg·d）]. Neutrophil and white blood cel counts were measured by blood routine；HE staining，ELISA measured serum levels of IL-6 ， IL-10 ，IL-1 β ， TNF- α and PGE2.Results Compared with the blank group，the number of neutrophils，leukocytes and neutrophil percentage increased significantly in the model group （ P<0.01 ）.Compared with the model group，the number of neutrophils，white blood cells and the percentage of neutrophils in the positive drug group and the low dose group decreased significantly （ P<0.01 ）. Compared with theblank group，themodel groupepitheliumwasatrophicandnecrotic，andsmallvesselsinthemembranepropria weredilatedand congested，showingmassiveinfiltrationofinflammatorycell.Comparedwiththemodelgroup，themucosaandsubmucosaofthepositivedruggroupwerebasicallyintact，sowngsateredifammatorycel；themucosandsubmucosaofteaerextrctweeelativelyintactandthemusclelayerwasthickenedwithinflammatorycelliiltration；thedamageofthewaterextractwasless；thelow dose group was more serious than the medium dose group. Compared with the blank group，the 1L-6 ， IL-Iβ ，TNF-α，and PGE2 levels increased significantly in the model group （ P<0.01 ）．Compared with the model group，the levels of 1L-6 ， 1L-1β ， TNF - α ，and PGE2 were significantly decreased in the positive drug group and the blank group （ P<0.01 ）；compared with the IL （20 -10 level in the blank group （ P<0.01 ）．Compared with the model group，the level of IL-10 was increased significantly in the positive drug group and the high，medium and low dose group （ P<0.01 ）.Conclusion On the level of local tissue inflammation factors.

Key Words：Poison Throat Prescription；Acute Pharyngitis；Inflammatory Factor

急性咽喉炎是发生在人体咽部黏膜、黏膜下组织及淋巴组织的急性炎症，主要症状包括声音嘶哑、发热、头痛、食欲不振、四肢无力、肌肉酸痛等[1]。（剩余7373字）