连翘水提物对副鸡禽杆菌抑菌机制研究
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关键词：连翘［Forsythia suspensa（Thunb.）Vahl]水提物;副鸡禽杆菌（Avibacterium paragallinarum）；连翘苷；高效液相色谱法；抑菌机制
中图分类号：S859.3 文献标识码：A
文章编号：0439-8114（2026）01-0131-06
DOI：10.14088/j.cnki.issn0439-8114.2026.01.022 开放科学（资源服务）标识码（OSID）：
Antibacterial mechanismof Forsythia suspensa aqueous extract against Avibacteriumparagallinarum
KANGHong-kai1，²，GUO Yun-qing²，ZHANG Teng-fei²， ZHANGWen-ting²，HU Qiao²， LUQin²，ZHANG Rong-rong²，ZHAI Xin-guo1，LUO Qing-ping²，3
（1.SchoolofLifFEnHbeUesitdnba;ybtoi andPoulryBacteraliseasPrevetionreparatiostoAgiculueanduralAis/HubeiProvicalKeybratoryfatc
MicrobiologyofiestcdoultialsbadydeernarstiteubaeiluralieshaO 3.HubeiHongshanLaboratory，Wuhan 430064，China）
Abstract：Avibacterimparagallnarumcausesinfectiouscorya，whichleadstodecreasedeggproductioninlayersandgrowthretar dationnbroilersesultingisignificanteconomiclosestotepoultryindustry.Withtheemergeneofulidrugresistanceandthe implementatioofantibiotic-estrictionplicies，tereisanurgentdtodevelogrenndfectiventibioticalterativ.Forst iasuspensa（ F .suspensa）possessesanti-inflammatoryandanti-infective properties.Thecontentofforsythinintheaqueous extractof F .suspensawasdeterminedusing High-performanceliquidchromatography（HPLC）.Theantibacterialeffectsoftheextractagainst Apgwereevaated，nudngitsipactonacteralgrowthiofiationesionndvasioncpabilis，hbeli narily elucidating itsantibacterial mechanism.Theresultsshowed thatthe forsythincontentinthe aqueous extract was （1.67±0.03）% ： Theminimuminhibitoryconcentration（MIC）andMinimumbactericidalconcentration（MBC）oftheextractagainstApg wereboth 7.81mg/mL .Theextractsignificantlyinhibitedbacterial growth，biofilmformation，andadesion-invasioncapabilities inadose-dependent manner.These findings demonstrated that the aqueous extract of F .suspensa exhibited potentinhibitory effectsagainst Apg in vitro，providing a potential strategy for developing eco-friendly agents to control Apg infections.
Key Words：Forsythia suspensa aqueous extract; Avibacterimparagallnarum；forsythin;Highperformane liquidchromatogaphy; antibacterial mechanism
副鸡禽杆菌（Avibacteriumparagallinarum）隶属巴氏杆菌科禽杆菌属，可引起鸡急性上呼吸道感染[1]。（剩余9614字）
