特殊口腔异位定植菌与慢性肝病的关系

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关键词：异位定植菌；代谢相关脂肪性肝病；肝硬化；肝肿瘤

基金项目：国家自然科学基金面上项目（82274352）；湖北省自然科学基金（2020CFA023，2023AFB426，2023AFD129，2023AFD178）

Association between ectopicallycolonized oral bacteria and chronic liver disease

HEJinglin'，LU Chenxia 2，3 ， LI Xiaodong2，4

1.ColegeofTraditionalChineseMedicine，HubeiUniversityofChineseMedicine，Wuhan43o65，China；2.InstuteofLier Diseases，HubeiKeyLaboratoryofTheoreticalandApliedResearchofLiverandKidneyinTraditionalChineseMedicine，Hubei ProvincialHospitalofTaditionalChineseMedicine，ClinicalResearchCenterforTCMliverDiseases，Wuhan43ool，China；3. Guang'anmenHospital，hinaAcademyfhineseMedicalSciences，IstituteofMetaboliciseases，Beijingo3，China;4. TheAffiliated Hospital of Hubei University ofChinese Medicine，Wuhan 43oo6l，China

Corresponding author： LI Xiaodong，lixiaodong555@126.com （ORCID： 0000-0002-6406-9416）

Abstract：Chronc liverdiseaseisageneraltermforavarietyof iverdiseases，anditsprevalencerateisincreasingyearbyyear. Withtheprogresionof thedisease，atients may experienceavarietyofseriouscomplicationsandevenprogrestoliverfailure.In recentyears，anumberofstudieshaverevealedtheassociationbetweenectopicallcolonzedoralbacteriaandchronicliverdisease andexploredtheirpotentialvalueinthediagnosisandtreatmentofchronicliverdisease.Thisarticlesystematicallreviews the asociationofetopicallcolonizedoralbacteriawithmetablicassociatedfattliverdisease，livercosisandlivercancerand analyzesthemechanismfortheinfluenceofectopicallcolonizedoralbacteriaonchonicliverdisease，soas toprovideaeference for the diagnosis and treatment of chronic liver disease using ectopically colonized oral bacteria.

KeyWords：EctopicColonzingBacteria；MetabolicDysfunction-AssociatedFatyLiverDisease;LiverCirhosis；LiverNeoplasms Researchfunding：NationalNaturalScienceFoundationofChina（GeneralProgram）（82274352）；NaturalScienceFoundationof Hubei Province（2020CFA023，2023AFB426，2023AFD129，2023AFD178）

慢性肝病是肝脏受到慢性持续性损伤，持续6个月及以上进行性肝功能恶化的肝脏疾病的总称，包括代谢相关脂肪性肝病（metabolic associated fatty liver disease，MAFLD）肝硬化和肝癌等。（剩余16280字）