甲状腺功能异常相关肝损伤的研究进展

Abstract：Thethyroid glandisthelargestendocrineorganinthehumanbody，anditsdysfunctioncancausevaryingdegresof liverinjury，leadingtoliverfailureinseverecases.Patientswithhyperthyroidismhavearelativelyhighincidencerateof liver dysfunction，manifestingashepatocellularinjuryorcholestaticliverinjury，whilehypothyroidismiscloselyassociatedwith metabolicdysfunction-associatedfattyliverdisease.Autoimmunethyoiddiseases，icludingHashimoto’sthyroiditisndubacute thyroiditis，arecommonly comorbid with autoimmune liverdisease.Inaddition，medicationssuchasantithyroiddrugs， amiodarone，andimmunecheckpointinhibitorscancausesevere liverinjurythrough directtoxicityorimmune-mediated mechanisms.Although significant progresshasbeenachieved inrelateddiagnosisand treatmenttechnques inrecentyears，there arestillmanychalenges inpathogenesis，individualizedtreatment strategies，earlywarning，andprognosticevaluation.This articlesystematicallreviewstheresearchadvancesinliverinjuryassociatedwiththyroiddysfunctionandproposesthedirections for future research，in order to provide guidance for clinical diagnosis and treatment.

Keywords：Hyperthyroidism;Hypothyroidism;Liver Injury;Therapeutics

Research funding：NationalNatural ScienceFoundationof China（821608O1）；Yunnan Province“TenThousand TalentsProgram’ Distinguished Physician Project（YNWR-MY-2020-018）

甲状腺与肝脏在生理和病理状态下存在密切联系，甲状腺主要分泌甲状腺激素（thyroidhormone，TH），其对机体代谢具有广泛调控作用，维持包括肝脏在内的全身代谢稳态[1]。（剩余15951字）