线粒体功能障碍在肝纤维化发病中的作用机制

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Abstract：Hepaticfibrosisrefers toexcesiveacumulationandabnormalproliferationoffibrousconectivetisueintheliver trigeredbymultiplepathogenicfactors，anditmayprogress tolivercirrosis，portalhypertension，andlivercancer.The pathologicalmchanismsofhpaticfbosisinvolvehepatoyteinjurylammatorycellinfiltratiowithtereleaseofiflatory mediators，hepaticstelatecellactivation，andextracelllarmatrixdeposition.Recentstudieshavefocusedonmitochondrial dysfunction indiseaseprogresion，including the molecular pathways for hepatic fibrosisdriven bymetabolicdisorders，energy deficiency，oxidativestress，mitochondrialdynamicimbalance，andautophagic dysfunction，allofwhichcan induceliverinjury. Thisarticlereviews thelatestadvancesinhepaticfibrosis，inordertoprovidenewtherapeuticstrategiesforclinicalmanagement.

KeyWords：Hepatic Fibrosis；Mitochondria;PathologicProcesses

Researchfunding：KeyScientificResearchProjectsofHigherEducationInstitutionsofAnhuiProvincialDepartmentofEducation （2023AH050733，2023AHo50783）；KeyCultivationProjectof Xin’an MedicalandTraditional Chinese Medicine Moderization Research Institute of Hefei Comprehensive National ScienceCenter Big Health Research Institute（2023CXMMTCM009）

随着慢性肝病的患病率逐年上升，世界卫生组织发现全球慢性肝病人数高达8.4亿，每年大约有200万人因该病死亡[1]。（剩余19829字）