大黄素防治慢性肝病作用机制的研究现状

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关键词：大黄素；肝疾病；信号传导

Abstract：Chronicliverdiseasesareagroupofdiseasesinwhichtheliverissubjectedtoavarietyof injuriesoveralong periodof time，resultinginirrversiblepathologicalchanges thatlastlongerthan6months.Emodin（EMO）isanaturalanthraquinone derivativederivedfromRheumoficinale，anditspharmacologicaleffecthasbeenextensivelystudied，exhibitingavarietyof biologicalpropertiesand involving multiplesignalingmoleculesand pathways.Westernmedicineorsurgical treatmentiscurently the maintreatmentregimen forchronic liverdiseases，andtheadvanceintreatmentislimitedbyvarious reasons suchas side efectsandhighcosts.Duetoitsnaturaloriginandficacy，EOasuniqueadvantagesinthetreatmentofchronicliverdiseases andhasnowbecomearesearch hotspot.Thisarticlesummarizes the therapeuticeffectofEMOonchronic liverdiseasesand its mechanism，nordertoprovideacertanscientificbasisforthetraditionalChinese medicinetreatmentofchonicliverdiseasesand the development of drugs in clinical practice.

KeyWords：Emodin；LiverDiseases；Signal Transduction

Researchfunding：National Natural ScienceFoundationofChina（82160845）；NaturalScienceFoundationofGansuProvince （25JRRA254，2OJR5RA181）；Traditional Chinese Medicine High LevelKey ScientificResearch Projectof Gansu Province （GZKZ2024-36）；ScientificResearch Start-upFundforIntroduced TalentofGansu UniversityofChinese Medicine（2O24-YJRC01）；Higher Education Innovation FoundationProjectofGansu Provincial Departmentof Education（2O21B-173）；Scienceand TechnologyPlanProjectofChengguanDistrict，Lanzhou City，GansuProvince（2O21-2-5）；FoundationofScientificResearchand Innovationof TCMof Gansu Universityof Chinese Medicine（KCZD2o18-1）；Graduate InnovationandEntrepreneurship Fundof Gansu University of Chinese Medicine（2025CXCY-008）

慢性肝病是一类以肝脏长期炎症、坏死和纤维化为特征的疾病，是导致慢性疾病死亡的主要原因之一，占全球死亡人数的 4%[1] 。（剩余19392字）