代谢相关脂肪性肝病种族和民族差异的影响因素

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Abstract：Metabolicassociatedfattliverdisease（MAFLD）isachronicliverdiseasecloselyasociatedwithmetabolicsyndrome， characterizedbyacomplexpathogenesisinvolvinggenetic，environmental，and lifestyle factors.Recent studies haveshown significantdispariesintheprevalencerateandclinicalfeaturesofMAFLDacross diferentracialandethnicgroups，andsuch disparities mightbasociatedwithvariousfactorssuchasgeneticbackground，nvironmentalfactors，socioeonomicdisparitis， andmetabolicprofiles.Thisarticlereviews thelatestresearchadvances inracialandethnicdiferences inMAFLDinChinaand globally，discusssitspotential pathogenicmechanismsandclinical significance，proposes futureresearchdirectionsand interventional measures，andemphasizes thecriticalneedtoenhanceMAFLDscreeningandpreventivehealtheducationin multiethnic populations.

KeyWords：Metabolic Associated Fatty Liver Disease；Racial Disparities；Ethnic Dierences

Research funding：NationalNaturalScience Foundationof China（8226Ol15）；Natural Science Fund Project of InnerMongolia AutonomousRegion（2O23QN08061）；Youth Exploration ProjectofAfiliatedHospitalof InnerMongolia Medical University （2023NYFYTS019）

代谢相关脂肪性肝病（metabolic associated fattyliverdisease，MAFLD）是较为常见的慢性肝病，全球患病率达 32.4% ，其流行病学特征表现出明显的种族/民族和地区异质性[1-2]。（剩余16379字）