阿司匹林在代谢相关脂肪性肝病中的作用

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关键词：代谢相关脂肪性肝病；阿司匹林；药物疗法

Abstract：Metabolicasociated faty liver disease（MAFLD）is the main typeof chronic liver disease inthe world，withan increasinglyhigherincidencerateandayoungerageofonset.Atpresent，thetreatmentofMAFLDmainlydependsonlifestyle interventionandcomorbiditymanagement，andthereisstillalackoffectivedrugsforMAFLDitself.Asaclassicnonsteroidal anti-inflmmatorydrugofthesalicylicacidfamily，aspirincaninterveneinthepathologicalprocesofMFLDbyreguatinglipid metabolism，relievinginsulinresistance，reducing liverinflammationandoxidativestressresponse，exertingananti-liverfibrosis effect，and inhibiting hepatocelularcarcinoma，andtherefore，ithasthevalueofpreventingdiseaseonset，delaying disease progresion，andreversingdiseasecondition.Thisarticlesystematicallreviews the mechanismofactionandsafetyofasprininthe treatment of MAFLD，in order to provide more drug treatment options for MAFLD patients.

Key Words： Metabolic Associated Fatty Liver Disease；Aspirin；Drug Therapy

Researchfunding：National Natural ScienceFoundationof China（82474419）;NationalAdministrationof Traditional Chinese Medicine HighLevelKeyDisciplineConstructionProjectofTraditionalChineseMedicine（zyzdxk-2O2305）;Capital’sFundsfor Health Improvement and Research（2024-1-2173）

代谢相关脂肪性肝病（metabolicassociated fattyliverdisease，MAFLD），既往称为非酒精性脂肪性肝病（non-alcoholicfattyliverdisease，NAFLD），是目前全球最为常见的慢性肝病之一，患病率为 25%～30%[1-2] 。（剩余13022字）