核因子E2相关因子2在急性肝损伤中的作用机制与治疗潜力

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关键词：核因子E2相关因子2；急性肝损伤；药理作用分子作用机制

Abstract：Acuteliverinjuryposesaserious threattothelifesafetyofpatients，andcurentlythereisstillalackofsatisfactory treatmentoptions.Asacytoprotetivetranscriptinfactor，nuclearfactorerythroid-relatedfactor2（Nrf2）hasimportantpotetial inthetreatmentofacuteliverinjuryNrf2exertsaprotectiveefectbyinducingtheexpresionofantioxidantenzmes，glating ironand fatyacidmetabolism，protecting mitochondrialfunction，andinhibitinginflammatoryresponses，anditcanalsoenhance theantioxidantcapacityoftheliverandinhibittheprogresionofacuteliverinjurybyactivatingantioxidantresponseelemennd promoting theexpressonof theantioxidantenzymessuchashemeoxygenase-1，glutathione transferase，andglutamate-cysteine ligasecatalyticsubunit.Nrf2canmodulateacuteliverinjurycausedbydiferent etiologies.Naturalcompoundssuch ascurcumin andsyntheticcompoundssuchasoltiprazcanactivate Nrf2through diferentmechanisms，enhancetheantioxidantcapacityof the liver，andthusexertaprotectiveefectagainstacute liverinjury.However，therearestillvariouschalengesinNif2inthe treatmentofacuteliverinjury，anditsmechanismofactionremainsunclear，withmoststudies inthestageofexperimentalstudyInthe future，itisexptedtodeplyivesigateteehaisofctioofteNf2sigalingpathwayiedrugdevelopntstategie， improvetheclinicalaplicationtheoriesforagonists，andprovidemorefectiveandpreisetreatmentegimesforpatintswithacute liver injury.

KeyWords：NuclearFactor-Erythroid2-RelatedFactor2；AcuteLiverInjury；MolecularMechansmsofPharmacologicalAction

Researchfunding：Shanxi Provincial Departmentof Scienceand Technology Shanxi ProvinceKey Country Scienceand Technology CoperationProject（2O210404110013）；ScienceandTechnologyInnovation TeamProjectof Shanxi Universityof TraditionalChineseMedicine（2O22TD2o3）；ShanxiProvinceKeyTeamofScientificandTechnologicalInnovationTalentsforthe PreventionandTreatmentofRheumaticImmunologywithIntegratedTraditionalChineseandWestemMedicine（2O2204050003）； ShanxiProvincialAdministrationof Traditional Chinese Medicine（2O24ZYYADoo8）；Natural ScienceFoundationof Shanxi Province（2O220302122272）；ShanxiUniversityof Traditional Chinese Medicine Scienceand Technology InovationCapacity DevelopmentProgramNationalNatural ScienceFoundationCultivationProject（2O24PY-NS-014）；ShanxiGraduateEducation Innovation Program Project（Outstanding Graduate Tutor Team Project）（2O24TD33）

急性肝损伤是指在无慢性肝病基础上，由各种病因导致肝脏细胞损伤而产生的疾病，临床上表现为血清丙氨酸氨基转移酶（alanineaminotransferase，ALT）、总胆红素（totalbilirubin，TBil）升高，如未及时治疗则会进一步发展为急性肝衰竭、肝性脑病等，严重影响患者的生命安全。（剩余26226字）