髓系细胞在肝纤维化中的作用及其机制

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Abstract：Hepaticfibrosis isacomplexdynamic process causedbymultiplechronic pathogenic factors，characterizedbyexsive accumulationofliverextracelularmatrixandabnormalliverstructureandfunction.Ifanti-fibrotictreatmentisnotperformedin time，itcanprogress tolivercihosisandevenlivercancer.Hepaticfibrosishasacomplexpathogenesis，andprevious studies mainlyfocusedontheactivationofhepaticstelltecellRecentstudieshaveshownthatmyeloidcellshavetepotentialofmultidirectionaldiferentitionandcanalsoparticipateinthdevelopmentandprgresionofhepaticfbrosis.Thisarticlesysteatialy reviewstheroleandregulatorymechanismofmyeloidcelsinhepaticfibrosis，inorder toprovideareferenceforclinicaldiagnosis and targeted therapy.

Keywords：Hepatic Fibrosis；MyeloidCells；Mechanism

Researchfunding：Cultivation Projectof PrecisionMedicine JointFundof Natural ScienceFoundationof HebeiProvince （H2025206096）；GovemmentFundedProject for Outstanding Talents in Clinical Medicine（ZF2024072）；HebeiProvince Traditional Chinese Medicine Scientific Research ProjectPlan（2O25320）

肝纤维化是由多种慢性肝损伤因素（如病毒感染、酒精性肝病、非酒精性脂肪性肝炎和胆汁淤积等）引起的肝脏细胞外基质（extracellularmatrix，ECM）过度沉积，是肝脏炎症进展为肝硬化甚至原发性肝癌的关键环节[1]。（剩余18441字）