子宫肌瘤与宫颈癌发病风险因果关系的两样本孟德尔随机化分析

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中图分类号：R737.33 文献标识码：A文章编号：1006-1959（2026）04-0042-05

Abstract：ObjetieTanalyethepotentialcausalrelatioshipetwenuterinefiboidsandeonsetriskofcervicalcancerbyMendelian randomization（MR）.MethodsThisstudyusedtwosampleMRtoanalyzethecausalrelationshipbetwenuterinefbroidsandtheosetiskof cervicalcanceiurecalestltplsalla studiosoftwarestactdlentatainGtabeIsdeesfiesaei Eggerregressoeigeddaetd，spleodedigddeeresedfodeliadozatioalssiii analysis， Cochran's Q testandMR-EggerinterceptmethodwereusedtotestwhethertherewasheterogeneityandhorizontalpleiotropyinMRanalysis results.TheoutliesereliaedbOodndtueceofchSoMultssaatedyaveouthod ResultsThetosapleManalysisasmainlysedontheIVWmethodadtheesultssowdtattereascausalrelatosiptween uterine fibroidsand the onset risk of cervical cancer （ P< 0.05），and uterine fibroidscould increase therisk of cervical cancer（OR=1.62，95%CI=1.28- 2.05）Iiaslasedal betwntheresultsofMRanalysisandtheesultsbefoeremovingSsbyheleaveoeoutmetodConclusionTosapleMRaalysisproves thatuterinefibroidscanincreasetheonsetriskofcervicalcancertoacertainextent，whichisariskfactorforcervicalcancer.

Keywords：Uterine fibroids;Cervical cancer;Mendelianrandomization;Onset risk

宫颈癌（cervicalcancer）是最常见的妇科恶性肿瘤之一，位居于女性恶性肿瘤第四位，仅次于乳腺癌、结直肠癌和肺癌。（剩余6874字）