甲胎蛋白、癌胚抗原联合细胞角蛋白19片段在结直肠癌患者中的表达及意义

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中图分类号：R735 文献标识码：A文章编号：1006-1959（2026）04-0018-05

Abstract：ObjectiveTostudythexpressionandsignificanceoflafetopotein（AP）carcinoembryoicatigen（EA）cobedih cytokeratin19fragnt-inatitsiortalaeretstotalfatitsitoalcedir hospitalfromJuar2tecebr4eseleedsthsechectsndyefidgouphilealcts ourhospitaluringteaeperdreseletedsgoupand49patientsitenigncoloretallsiosingtesaeperodeeeted groupA.TeelsfoksE，RA-，cheoaddeelsfwithiet wereanalyzedMulilegisticegresoasedtoalhdependesfctosof，CEadCRA-1ederte receiveroperaoacteiiOdtalftasosooloal levelsofCEA，FRA1-andAFPingrouCwerehigertantoseingroupAandgoupBndtoseingrouAwerehighertathosen groupB（ PΦ <0.05）.IngroupC，therewasnosignificantdierenceinthelevelsofAF，CEAandCYFRA1-incolorectalcancerpatitsith different gender，age，tumor location and tumor diameter （ P> 0.05），but there was significant difference in the levels of AFP，CEA and CYFRA21-1 in colorectal cancerpatientswith different diffrentiationdegree，clinical stageand lymph nodemetastasis（ P< 0.05）.MultipleLogisticregressionanalysis showedthatlcalagesanidepedentiskfctforeevatedlevelsofAF，CEAandFRA-inpatientsiholoretalce（ P< 0.05）.ThesiidseEiinossdreaefloalce those of single tumor markers（ P<0.05） .Conclusion SerumAFP，CEAand CYFRA21-1levelsarecloselyrelated to themalignant progressionof colorectalcadestfaass

wasaninepedentifuecingfactorfortheelevatioofteabovemarkers.Combdetectioncanimproveedetectioefiecndas auxiliary reference value for evaluating the progression of colorectal cancer.

KeyWords：Colorectal cancer;AFP;CEA; CYFRA21-1; Diagnostic efficiency

随着社会经济的发展及居民生活水平的提升，结直肠癌（colorectalcancer）发病率不断提高，目前已经成为我国发病率位居第四的常见恶性肿瘤。（剩余8009字）