肌少症潜在遗传机制的全基因组关联研究

打开文本图片集

中图分类号：R58；R685文章编号：1006-1959（2026）04-0001-07

文献标识码：A

DOI：10.3969/j.issn.1006-1959.2026.04.001

Genome-wide Association Study on the Potential Genetic Mechanism of Sarcopenia

PENGHuan1，FANGHan1，YEQiang1，QIMengyao1，CHENXiaomin1，HUANGJie² （1.The Second ClinicalCollgeof Zhejiang Chinese MedicalUniversity，Hangzhou 310o53，Zhejiang，China; 2.DepartmentofGeriatrics，theSecondAfiliated Hospitalof Zhejiang Chinese MedicalUniversity，Hangzhou，

Zhejiang， China）

Abstract：OjectiveToeealteotentilgeneticecanismofrconiabyenomewidsociationsudy（WA）andtoiew moleculartargetsfoarlyagosisrevetiondreaentoftiseaseetodsAotalofderlyopleodopedole genomesequencingintheZejangProvicialElderlyHealthCohortfroJnuaryO18toDecember2 ereselectedFromJuarytJu 2024，139ofteereradolyseletedforeasurementandtypinaalysisofarcopeelaedindicatorsndGWasout. ResultsToasiingeletidelos）ralledchebdi Eachoftheeihtshrhr5h8，l14d）adgiooatedio anotaedncudeKACBEM08，D，B3，ARC1，NV2，C7Bnd28A1.Aerlnagesequlib（LD）alst westilltwolciwitoutlkagediseqlibiKACB，EM8ndARMC1gnes.CocusioItissudy5Slocitedih sarcopeniaarefoundolving8ooosd3enongichKCB8ndesvedepeentloci revealing the potential genetic mechanism of sarcopenia.

Keywords：Sarcopenia;Genome-wide association study;Genes

肌少症（sarcopenia）是一种与年龄相关的肌肉量减少和功能下降的综合征，其特征为骨骼肌质量和力量显著减少，最终导致身体功能受限和生活质量下降[。（剩余5229字）