姜黄素对缓慢葡萄球菌感染性皮肤损伤的治疗作用分析

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中图分类号：S852.61 文献标志码：A 文章编号：1671-4652（2025）06-0031-10

Analysis of the therapeutic effect of curcumin on Staphylococcus lentus-infected skin lesions

LIU Jingjing，ZHOU Yiting，SHI Xiaochun，WANG Shuo，ZHENG Yuxin， ZHU Liqi， CHEN Xiang， CHEN Bing

（Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses /

Jiangsu Key Laboratory of zoonosis/ Institute of Comparative Medicine /

College of Veterinary Medicine， Yangzhou University ，

Yangzhou 225009，China）

ABSTRACT：To explore thetherapeutic efectofcurcuminonskin infectioncaused by Staphylococcus lentus，we isolated andidentifieda strain of S.lentus froma diseased mice.Subsequently，a mouse skin infection model was established to analyzethe pathogenicityof the bacteriaand evaluate the therapeuticefectof curcumin.Theresults showed thatthe dermallayerofthe woundtissueofthebacterial infection grouphadinflammatorycellinfiltration，and theregenerationof hair foliclesandcollagen fibers was reduced.Immunohistochemical results showed that the numberof macrophage surface markersF4/8O increased，and fluorescencequantitative results showed that the mRNA transcription levels of cytokines IL-6 and IL–Iβ was increased; in the curcumin group，the wound healing rate was accelerated，collagen fibers were regenerated in the dermis，the number of CD-34 and TGF-β positive cells increased，and the relative expression of IL-6 and IL–1β mRNA was decreased. In conclusion，S.lentus can aggravate skin wound tissue damage and inflammatory response. Curcumin ：an abate the corresponding pathological damage and promote collagen fiber regeneration and wound healing.

KEY WORDS： mice; S. lentus; curcumin; infectious skin wounds; inflammatory response

缓慢葡萄球菌（Staphylococcus lentus，S.lentus）是一种凝固酶阴性葡萄球菌（coagulase-negativeStaph ylococci，CNS），属于葡萄球菌属[1-2]。（剩余15310字）