2种含氟涂料对低龄儿童龋病社区干预的效果与成本分析

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[中图分类号] R780.1 [文献标志码] A [doi] 10.7518/hxkq.2026.2025174

[Abstract] Objective Acommunity intervention model was used to investigate the preventive effects and cost-effectiveness of I-ReHealth？ and Duraphat？ in early childhood caries.MethodsChildren from Yizhou District，HechiCity，were enrolled and randomlyassigned into two groups：the I-ReHealth？group and the Duraphat？group.Each group received topical fluoride varnish applications and dental health education every6months.After1.5 years，the incidence of cariesand associatedcosts were compared betweenthetwo groups beforeand afterthe intervention.Cost minimization analysis was employed to evaluate economic eficiency，and sensitivityanalysis was performed toasessteinfluenceofvariations inkeyparametersonresult stabilityandtoquantifytheprobabilisticdiferences in costbenefits between thetwo fluoridevarnishes underequivalentcaries-preventiveefects.ResultsPriortotheintervention，we found no statistically significant diferences in caries prevalenceor mean dmft scores between the two groups （P>0.05） .After1.5 years of treatment，both groups still showedno statistically significant differences in caries prevalence （P>0.05） ，meandmft scores （P>0.05） ），cariesincidencerate （P>0.05） ），orincrement inmean dmft （P>0.05） 一 The one-sided 97.5% confidence interval for the difference in mean dmft increment was below the non-inferiority threshold，confirming non-inferiority （P<0.025） .Cost minimization analysis revealed lower total costs in the I-ReHealth？ group （？25 411.44） than in the Duraphatgroup （？26 692.98）.One-waysensitivityanalysis identified material price as the most influential parameter affecting total costs.Monte Carlo simulation with 1 000 iterations demonstrated a 73.1% （2号 probability thattheI-ReHealthgroup willyield cost savings compared with the Duraphat® group.ConclusionI-ReHealth® isnon-inferiorto Duraphat？ incaries-preventiveeficacy but superior incost-effctivenessinreducing patient expenses.

[Key words] early childhood caries; fluoride varnish; community-based intervention; cost minimization analysis

龋病作为一种慢性非传染性疾病，已成为全球重大公共卫生问题，影响人类口腔健康-3]。（剩余11045字）