花椒精油微胶囊咀嚼片配方及降脂性能研究

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Abstract：To explore the preparation process and in vitro hypolipidemic activityof Zanthoxylum bungeanum esential oil microcapsulechewable tablets，therebyenhancing theiraplication value，this studyinvestigates the aditionamounts ofraw materials，skimmedmilkpowder，swetenersandfillersviasingle-factorexperimentsandorthogonaltests，anddeteines thetablets'hardnes，weightvariation，thickness，moisturecontent，invitrohypolipidemiccapacityandhygieneindicators. The optimal formulation for the chewable tablets is as follows： 6% raw material addition， 40% skimmed milk powder， 18% （20号 sweetener， 35% filler， 0.5% citric acid，and 0.5% magnesium stearate.Under this formulation，the tablets achieve a 55.4% adsorption rate for sodium taurocholate， 50.5% for sodium glycocholate. The cholesterol adsorption rate is 39% at pH2.0 and 48.3% at pH7.0 .The total number of colonies in the chewable tablets is measured at <10CFU/g ，coliform count at < 10CFU/g ，and no lead is detected.All indicators complywith thenational standards.The Zanthoxylum bungeanum essential oil microcapsulechewable tablets exhibitapleasanttaste，satisfactorychewabilityanddefinite lipid-lowering capacity. Keywords：Zanthoxylumbungeanumessentialoilmicrocapsules;chewabletablets;directcompression;hypolipidemic

花椒精油中含有 90% 的不饱和脂肪酸，其中主要为 a -亚麻酸、亚油酸等，它们属于 n-3，n-6 长链多不饱和脂肪酸[1。（剩余10922字）