JAK2/STAT3信号通路及其抑制剂在弥漫大B细胞淋巴瘤中的研究进展

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中图分类号 R979.1;R733.4 文献标志码A 文章编号1001-0408（2026）05-0682-07

DOI 10.6039/j.issn.1001-0408.2026.05.23

Advances in the JAK2/STAT3 signaling pathwayand its inhibitors in difuse large B cell lymphoma

LU Chuanyang1，²，CHEN Qiuni1，2，SHI Yuyel，²，DENG Yuan1，²，JI Tingting1，2，LIU Zhengyuan1²，WANG Chunling'²，YULiang1，²（1.Dept.of Hematology，the Afiliated Huaian No.1 People's Hospital of Nanjing Medical University，Jiangsu Huai’an 223300，China；2.Key Laboratory of Hematology，NanjingMedical University，Nanjing ，China）

ABSTRACTAbnormal activationof the Janus kinase/signal transducerandactivatorof transcription（JAK/STAT）signaling pathway is involvedinthepathogenesisofdifuselargeB-cellymphoma（DLBCL）.Inrecentyears，inibitorstargetingJAK2and STAT3 haveemerged aspromising therapeuticcandidates in DLBCL.Thisreview summarizes theeficacyand safety profilesof JAK2inhibitors（e.g，ruxolitinib）andSTAT3inhibitors（directsmall-moleculeinhibitors，theantisenseoligonucleotide，and proteolysis argetingchimeras，etc.）inpreclinicalmodelsandclinicaltrials.AccumulatingevidenceindicatesthatJAK2andSTAT3 inhibitorsexhibitantitumoractivityandare generallywelltoleratedinasubsetofDLBCLpatients.Meanwhile，thedevelomentof noveldrugdeliverysystemshassignificantlyenhancedthestability，bioavailabity，andtargetingabilityofthecompounds. Furthermore，JAK2and STAT3inhibitorsmayexhibitsynergisticefectswhencombined withothertherapystrategies（suchas combinationswithB-cellreceptorsignalingpathwayinhibitors，immunomodulators，orothertargeteddrugs）.However，curent clinicalappicationsarestillinthrarlystages.Futureresearchsouldconcentrateonprecisiontreatmentstrategiesbasedonth genetic subtypingofDLBCL，and furtherrefinethedeliverysystems forinhibitorsaswellascombinationdrugregimens to improve clinical outcomes.

KEYWORDsJanuskinase；signaltransducerandactivatoroftranscription；difuselargeB-celllymphoma；ruxolinib; proteolysis targeting chimeras

恶性淋巴瘤是一组起源于淋巴结和淋巴组织的具有异质性的血液系统肿瘤，根据其组织病理学特征主要分为霍奇金淋巴瘤（Hodgkinlymphoma，HL）和非霍奇金淋巴瘤（non-Hodgkinlymphoma，NHL）两大类。（剩余16386字）