藏药湿生扁蕾及其活性成分抗溃疡性结肠炎及相关纤维化的机制研究进展

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中图分类号R28；R96 文献标志码A 文章编号 1001-0408（2026）05-0676-06

DOI 10.6039/j.issn.1001-0408.2026.05.22

Research progresson the mechanisms of Tibetan medicine Gentianopsis paludosa and its chemical components againstulcerativecolitisand associated fibrosis

LI Huan'，NIE Qing²，AN Yongkang'，ZHANG Shuangxi1，ZHANG Xiang'an1（1. Dept. of Anorectology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;2.The Fifth Clinical College，Henan University of Chinese Medicine，Zhengzhou 45o046，China）

ABSTRACTUlcerativecolitis（UC）isachronicandrelapsing inflammatorydiseaseoftheintestine.Intestinalfibrosisrepresents aseverecomplicationandapotentialriskfactorformalignanttransformation.Gentianopsispaludosaisoneofthetraditional Tibetanedicinescommonlyusedfortreatinggastrointestinal disorderssuchasdamp-heatdiarrheaanddysentery.Itschemical compositioniscomplex，encompasingxanthones，flavonoids，terpenoids，andotherbioactivecomponents，anditexhibits propertiessuchasclearing heat，eliminating dampness，and detoxifying.Thisarticlereviewstheresearchprogressonthe pharmacodynamic material basis and mechanisms of G ：paludosa against UC and associated fibrosis.Findings suggest that its extracts（e.gaqueousextract，ethylacetateextract）andactivconstituents（e.g.ydroxy-3，7，-rimethoxyanthonsolic acid，swertiamarin，luteolin）mayinhibitinflammatorycytokines，combatoxidativestress，suppresscellapotosis，regulate intestinalmicrobotaandtheirmetaboites，protecttheitestialmucosalbarier，modulateimmuneresponsesndihibitielial mesenchymal transition，throughmodulatingrelevantsignalingpathways，suchasuclearfactor-kappaB，B-cellymphom-2（Bcl2）/Bcl-2-associated X protein，and transforming growth factor- β1/Smad ， thus exerting therapeutic effects against UC and its related fibrosis via these seven aspects.

KEYWORDsGentianopsispaludosa；ulcerativecolitis；intestinalfibrosis；xanthones；flavonoids；activeingredient；mechanism of action

溃疡性结肠炎（ulcerativecolitis，UC）作为炎症性肠病（inflammatoryboweldisease，IBD）的主要亚型，是一种以结肠黏膜持续炎症和上皮损伤为特征的慢性进展性疾病。（剩余13363字）