中药有效成分调节生物钟节律干预慢性心力衰竭能量代谢障碍的研究进展

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中图分类号R972；R965 文献标志码A 文章编号 1001-0408（2026）05-0670-06

DOI 10.6039/j.issn.1001-0408.2026.05.21

Research progress on the intervention of energy metabolism disorders inchronic heart failurebyactive ingredients of traditional Chinese medicine through regulating circadian rhythms

GUO Ruiqi1，23， WANG Sutong，LYU Zhaohui，LI Yan1，GUAN Renwei²，LI Xiao4（1. The First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan 250355，China;2. Shandong Academy of Chinese Medicine，Jinan 250014，China;3. State Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs，Beijing 100700，China;4.Dept.of Cardiology，the Afiliated Hospital of Shandong Universityof Traditional Chinese Medicine，Jinan 250014，China）

ABSTRACTTheonsetandprogressonofchronic heartfailure（CHF）arecloselyassociatedwithmyocardial energymetabolism disorders，andthispathologicalprocessignificantlyafectspatient prognosis.Traditional Chinesemedicie（TCM），groundedin time-basedmedicaltheoriessuchasthecorespondencebetweenhumansandnatureandthetheoryofcircadianflowofmeridians （ZiwuLiuzhu），exhibits intrinsicconsistencywith moderncircadianrhythmtheory，providingauniquetheoreticalframework for understandingand interveninginCHFfromatemporal perspective.Thisarticlesystematicallyexplores theimpactofcircadian rhythmsonenergymetabolismandthepotentialmechanismsbywhichTCMactiveingredientsinterveneinCHFthroughareview ofrelevantliterature.ItisfoundtatvariousTCMactiveingredients，includingflavonoids（suchasnobiletin），alkaloids（suchas berberine），andpolyphenols（suchasresveratrol），canimprovemitochondrial function，promotefattyacidoxidation，enhance glucose uptakeandutilization eficiency，maintain metabolicbalance，andalleviateoxidativestressand inflammatoryresponses in myocardial cels byregulating the expression and rhythms ofcore circadian clock genessuch as CLOCK，BMAL1，PER，and CRY.Theseactionstherebycorrectenergymetabolismdisordersandimprovecardiacfunction.Furterexplorationof theinteractionmechanisms between these components and the circadian rhythmsholdspromiseforprovidingnovel theoretical foundations and potential intervention strategiesforthe preventionandtreatmentofCHF.

KEYWORDS circadian rhythms； chronic heart failure;energy metabolism； traditional Chinese medicine； activeingredients

慢性心力衰竭（chronicheartfailure，CHF）是一种以心室收缩或舒张功能障碍、心排血量下降为主要特征的严重临床综合征，处于各类心脏疾病的终末阶段。（剩余13642字）