2型固有淋巴细胞及其细胞因子在2型炎症性疾病中的作用机制

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【 Abstract】Type 2 innate lymphoid cels （ILC2s） originate from common lymphoid progenitor cels and are mainly distributed atbarrersitessuchastheskin，respiratorytract，andintestines，serving asanimportantcomponentoftheiate immunesystem.StudieshaveconfirmedthatILC2sparticipateinthepathogenesisoftype2inflammatorydiseases，suchaatopic dermatitis，rocalaalgicitisonicosisitsithsaolsoodlergydinoliciis. Theyare not only early source cels of type 2 cytokines，but can also jointlyregulate the inflammatory process through interactions withothrimmunecellsandstucturalcell.Curentlytherapeuticstrategiesinvolvingtargetedinterventiosthe activation，migrationandeffectorfunctionsofILC2shavebecomearesearchfocus.Thisreviewsystematicallelaboratesonthe biologicalcharacteristicsofILC2sand mechanismsbywhichtheyparticipate intype2inflammatorydiseases，aiming toprovidea theoretical basis and research ideas for clinical intervention in type 2 inflammatory diseases.

【Key words】 Type 2 innate lymphoid cels; Type 2 inflammatory disease; Cytokines; Pathogenesis; Targeted therapy

2型炎症反应是由适应性免疫和固有免疫及其相关细胞因子所共同介导的一类炎症反应，二者协同作用构成其病理生理基础［1]。（剩余15506字）