竞争性内源性RNA网络在慢性肾衰竭中的作用及中医药干预研究进展

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【Abstract】Chronic renal failure （CRF） is associated with multiple complications，a poor prognosis，and limited therapeutic options.Recent studies haveshownthat thecompetitive endogenous RNA （ceRNA）network mediatedbylong noncoding RNAs （lncRNAs）andcircular RNAs is widely involved in pathological proceses of CRF，such as inflammation activation，oatissoosisalistacellaratrioptdctulmodelgdisIt mediates theformationofthepathologicalloopof“nflammation-ijury-fibrosis”duringtheprogresionofCRF，thusmakingita potential therapeutic targetHowever， most current studies focuson asingle ceRNAaxis and lack systematic analysis of the centralnodesanddynamicregulatorymechanismsofthenetwork.Thisarticlereviewsthemechanismof theceRNAnetwork in CRFand analyzes theintervention effectoftraditional Chinese medicine（TCM）onkeytargets oftheceRNAnetwork，providing anewperspectivefor interpreting the efects ofTCMfromtheperspectiveof molecularbiology.The“multi-component， multitarget”characteristicofTCMishighlyconsistentwiththecomplexityoftheceRNAnetwork.TCMcanefectivelydelaythe occurrence anddevelopmentofCRFthroughmultiplepathways，suchasantiiflammation，anti-renalfibrosis，improvingcel injury and apoptosis， and reducing extracellular matrix deposition.

【 Key words】 Chronic renal failure; Traditional Chinese medicine; Competitive endogenous RNA network; Long non-coding RNA; Circular RNA

慢性肾衰竭（chronicrenalfailure，CRF）是指在各种慢性肾脏病基础上出现肾功能进行性减退、肾小球滤过率下降，导致人体代谢产物潴留、水电解质紊乱、酸碱平衡失调，引起全身各系统症状的一种临床综合征［1]。（剩余22079字）