溃疡性结肠炎脾肾阳虚证动物模型构建及评价方法的研究进展

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[中图分类号］R-332 [文献标志码］A [文章编号]0257-358X（2026）04-0435-08

DOI：10.16295/j.cnki.0257-358x.2026.04.017

Research Progress on Construction and Evaluation of Animal Models for Ulcerative Colitis with Spleen-Kidney Yang Deficiency Syndrome

WANG Jing，HE Xiaoqin，HUANG Xiaoting，ZHANG Bisheng，WEI Yu'na （Basic Medical College，Guangxi University of Chinese Medicine，Nanning 53O2Oo，China）

AbstractThe disease-syndrome combined animal model，constructed based on the concept of syndrome differentiationand treatment，serves asa crucial approach for investigating the mechanisms underlying traditional Chinese medicine's intervention in the spleen-kidney yang deficiency syndrome in ulcerative colitis （UC）.Analyzing the advantagesand limitations of existing methodscan offer insightsand references for establishinga standardized disease-syndrome combined animal model and its associated evaluation systems. Through a comprehensive review of the recent literature on animal models of spleen-kidney yang deficiency

syndrome in UC，this study has found that the current construction of such animal models in UC primarily combines the etiology and pathology-based modeling method with the chemical reagent method. The models constructed using this approach possess advantages such as high success rate，good stability， typical pathological changes，and high clinical con

sistency.However，the methodof establishing modelsbycombining etiologyand pathology has theproblem of non-unified drug administration cycle and dosage.The model evaluationsystem encompasses macroscopic characterization，physical and chemical indicators，and syndrome verification via formulas，presenting a relatively comprehensive approach.Nevertheless，the weights of each indicator remain unclear.There are 60 references.

Keywordsulcerative colitis;spleen-kidneyyang deficiency syndrome;animal model;molding method;evaluation method

溃疡性结肠炎（UC）是我国高发的炎症性肠病之一，临床症状以腹泻、腹痛及黏液脓血便为主，病情易反复且病程迁延，严重影响患者的生活质量，严重者甚至可能并发肠穿孔、大出血及癌变等[]。（剩余14502字）