基于“骨极"理论从“肺-肾-骨"轴探讨肺癌骨转移的形成机制与临床防治策略

[中图分类号］R273 [文献标志码］A DOI：10.16295/j.cnki.0257-358x.2026.04.004

[文章编号]0257-358X（2026）04-0360-06

Exploration of Formation Mechanism and Clinical Prevention and Treatment Strategies of Bone Metastasis in Lung Cancer from“Lung-Kidney-Bone”Axis Based on “Extreme Bone Weakness” Theory

ZHOU Enguang1，GAI Jingchun1，ZHAO Zheng'，GAO Fei 1，2 ，SONG Aiying1，2 （1.Graduate School of Heilongjiang University of Traditional Chinese Medicine，Harbin 15o040，China; 2.Department1of Oncology，The First Afiliated Hospital ofHeilongjiang Universityof Traditional Chinese Medicine，Harbin ，China）

AbstractBone is one of the common metastatic sites of lung cancer.In patients with lung cancer，due to theinvasion of thelungs by cancer toxins，the diseasespreads from the mother-organ（lung）to the childorgan（kidney），resulting in deficiency of the kidneyand inadequatenourishment for the bones.Meanwhile， cancer toxins can directly damage the kidneys and bones，and then the condition progresses to thestate of “extreme bone weakness.Combining with the“extreme bone weakness”theory，this article starts from the “lung-kidney-bone”axis to systematically explore the correlations between qi deficiency of lung and kidney， kidneydeficiency，bone malnutrition and factorssuch as circulating tumorcells（CTCs），immune cels，

epithelial-mesenchymal transition（EMT），andpremetastatic niche（PMN）in the microenvironment of bone metastasis in lung cancer.It also analyzes the application of the methodof tonifying the kidney and strengthening the body resistance in the prevention and treatment of bone metastasis in lung

cancer，providing ideas for traditional Chinese medicine intervention in bone metastasis in lung cancer. Keywordslung cancer;bone metastasis;lung;kidney；extreme bone weakness；tonifying the kidney and strengthening the body resistance

肺癌的发病率和病死率在我国乃至全球癌症中均居首位，且随着全球化进程的推进，其发病率呈现出上升趋势。（剩余10489字）