疏调气机方治疗艾滋病合并高脂血症相关靶基因预测分析

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中图分类号：R512.91 文献标志码：A 文章编号：1007-2349（2026）02-0040-07

Analysis of Predicted Target Genes for AIDS Complicated with Hyperlipidemia Treated by the Prescription for Regulating the Flow of Qi

LU Zhong -yun，LI Wei，WEN Ji-hong， XIA Hai- mei，PU Ya-ping，GAO Wen -jun，WANG Li （Yunnan Institute of Traditional Chinese Medicine and Materia and Medica，Kunming 650223，China）

【Abstract】Objective：To explore the therapeutic eficacy-related gene targets of the prescription for regulating theflowofqi bynational medical master Zhang Zhen for AIDS complicated withhyperlipidemia through high-throughput sequencing and to clarifyits efective mechanism.Methods： Clinical patients with AIDS complicated with hyperlipidemia werecollctedand treated with this prescription in the formofdecocted-freegranules for3months.Eight patients with efective lipid-lowering inAIDScomplicated with hyperlipidemia were selected.The expressionof microRNA（miRNA）in the patients’ blood beforeand after treatment wasdetectedby high-throughput sequencing.The differentially expressed genes were analyzed by GO and KEGG bioinformatics，and the possble pathways through which the prescription might exert its effects were predicted.Results：A total of 97diferentiallyexpressed genes related to the therapeutic efficacy of the prescription were identified （ P<0.05 ），including 56 up - regulated genes and 41 dow -regulated genes.The therapeutic mechanism of the prescription may be related to metabolic pathways，cancer pathways，calcium signaling pathways，axon guidance， PI3K -Akt signaling pathways，Ras signaling pathways，Rap1 signaling pathways，cytoskeleton regulation，cGMP-PKG signaling pathways andadhesion pathways. Conclusion： The key pathways of the prescription in treating AIDScomplicated with hyperlipidemia may be metabolic pathways and ncGMP-PKG pathways.The exploration of the target genes of the prescription canprovidea basis forTCM treatment of AIDS complicated with hyperlipidemia.

【Key Words】National Medical Master; Zhang Zhen; Prescription for Regulating the Flowof Qi; AIDS;Hyperlipidemia；Target Gene

人类免疫缺陷病毒（HIV）／获得性免疫缺陷综合征（AIDS）患者接受高校抗逆转录病毒治疗（HAART）治疗可导致脂代谢紊乱，出现血脂异常，是导致心血管事件发生的高危因素之一。（剩余9093字）