基于PI3K/Akt/NF-kB信号通路的中药治疗溃疡性结肠炎机制研究进展

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中图分类号：R574.1 文献标志码：A 文章编号：1007-2349（2026）01-0085-08

【Abstract】Ulcerative colitis（ulcerativecolitis，UC） isa chronic intestinal inflammatory disease with anunknown pathogenesis.The gradual increase in its incidence and the younger age of patients have madeitamajor chronic disease threatening human health.The PI3K/Akt/NF-kB signaling pathway plays a crucial role in the occurrence and development of UC by regulating biological processes such as inflammatory responses and cellsurvival.Modern medical treatment for UC stillhasproblemssuchaslimited effcacyand manysideefects.Therefore，developing newtargeted drugs and clarifying their mechanisms of action are the currnt research focuses.A large number of studies have confirmedthattraditional Chinesemedicinecan intervene inthis pathway through multipletargets，thereby inhibiting he releaseof inflammatory factors，repairing the intestinal mucosal barier，regulating immune balance，andreducing oxidative stress damage to prevent and treat UC.Based on this，taking the PI3K/Akt/NF-kB pathwayas the entry point，this paper explores its key role in the pathogenesis of UC and summarizes the therapeutic mechanism of TCM intervention in this pathway，with the aim of providing a reference for targeted therapy of UC.

【Key Words】Ulcerative Colitis; PI3K/Akt/NF- kB Signaling Pathway; TCM Compound ; Single Chinese Herb

溃疡性结肠炎（ulcerativecolitis，UC）属于慢性非特异性肠道炎症性疾病，病变主要累及直肠、结肠黏膜和黏膜下层组织，典型症状为反复发作的腹痛、腹泻、黏液脓血，还可能伴随皮肤、黏膜等肠外表现[1其发病机制与遗传易感性、上皮屏障缺陷、免疫调节异常、微生物菌群失调及环境等多方面因素相关[2]受生活方式和饮食结构变化的影响，该疾病全球发病率呈上升趋势，北美、欧洲等发达国家发病率较高，我国的发病率虽低于西方国家，但近年来同样呈现出明显的上升趋势

中医学依据UC呈现的腹痛、腹泻、便脓血、里急后重等症状，将其归为“痢疾”、“肠澼”、“大疲泄”等范畴[3]。（剩余17943字）