微小RNA在结直肠癌上皮间质转化中的作用与研究进展

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【中图分类号】R735.3 【文献标识码】A

【Abstract】 Colorectal cancer （CRC） is the third most common cancer globally， with an incidence rate ranked just behind lung cancer and breast cancer in women.Epithelial-mesenchymal transition （EMT） enhances the migratory and invasive abilities of tumor cels but is also closely associated with tumor recurrence and drug resistance.MicroRNAs （miRNAs） are a class of noncoding RNAs that regulate the EMT process through various mechanisms and pathways.Therefore， this review aims to summarize the roles and research progress of miRNAs in the regulation of EMT in CRC，providing new insights into the complex regulation of EMT and ofering potential strategies for the prevention and treatment of CRC metastasis.

【Keywords】Colorectal cancer; Epithelial-mesenchymal transition; MicroRNA; Drug resistance; Natural compound

结直肠癌（colorectalcancer，CRC）是导致癌症患者死亡的第二大原因，2022年全球CRC新发病例为192.61万例，死亡90.39万例[]。（剩余16733字）