FGF21与视网膜新生血管性疾病的研究进展

【中图分类号】R774 【文献标识码】A

【Abstract】Retinal neovascularization （RNV） diseases are one of the leading causes of visual impairment and blindness， including diabetic retinopathy， retinopathy of prematurity， retinal vein obstruction，and wet age-related macular degeneration. In recent years，fibroblast growth factor 21 （FGF21），a multifunctional metabolic regulator， has been found to exert a significant inhibitory effect on RNV.Therefore，this article systematically reviews the biological characteristics of FGF21， its molecular regulatory mechanisms in RNV diseases， and its potential therapeutic applications， aiming to provide a theoretical basis for developing novel FGF21-based treatment strategies for retinal diseases.

【Keywords】Fibroblast growth factor 21; Retinal neovascularization; Diabetic retinopathy; Retinopathy of prematurity; Age-related macular degeneration; Retinal vein obstruction

视网膜新生血管（retinalneovascularization，RNV）性疾病是一组以病理性血管增生为特征的致盲性眼病，主要包括糖尿病视网膜病变（diabeticretinopathy，DR）、早产儿视网膜病变（retinopathyofprematurity，ROP）、湿性年龄相关性黄斑变性（wet age-related macular degeneration，wAMD）、视网膜静脉阻塞（retinalveinobstruction，RVO）等，其共同病理特征是异常血管形成，导致视网膜出血、渗出甚至牵引性视网膜脱离[1-2]，最终造成不可逆的视力损害。（剩余17279字）