基于数据挖掘、网络药理学与分子对接探讨肥胖相关性高血压的用药规律及作用机制

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AbstractObjective：ToinvestigatethemedicationpaternsoftradionalChinesemedicine（TCM）fortreatingobesityrelated hypertensionandtoexplorethepotentialmechanismsofctionunderlyingkeyherbpairs.Methods：LiteratureonTCMtreatmntfor obesity-relatedhypertensionwasretrievedfromCNKlWanFangDataVI，andCBM.Rlanguagewasusedformedicationpattem analysis.Networkpharmacologywasthenappliedtoidentifycoreherbpairsandtheirkeyactivecomponentsandtherapeutictargets. Subsequentlymoleculardockingwasconductedforvalidation.Results：Atotalof10CMsubstanceswereincudedintheatamining analysis.TepolarseinliatataorcsstroaelataCtruseticataelndractysacre herbspredominantleibitedamproperties，tastedsweet，ierrpungentndprimarlyctedonthespleenandliverdans. Theirfunctionsmainlyincudedtonifyingpromotingbloodcirculationtremovestasis，promotingduresisandresolvingdmpsand calmingtheliverandsuppresingwindNetworkpharmacologyanalysisidentfed33activecomponentsfromthecoreherbpirshich intersectedwith103obesity-relatedhypertensiontargets.Geneontology（GO）analysisandKyotoEncyclopediaofGenesandGenomes （KEGG）enrichmentanalysissuggestedthattheseactiveingredientsmightreatobesityrelatedhypertensionbymodulatingpathways suchasneuroactiveligandeceptrnteractionsulinesistanceandthersMoleculardockindicatedfavoablebdintente corecomponentsandkeytargets.Conclusion：TCMtherapyforobesity-relatedhypertensionprimarilyfocusesonstrengtheningthe spleentoresolvedampnessandplegm，calmingtheliverandextinguishingwindndpromotingbloodcirculationtoresolvestasis. Mutipleeffetiveactiveingredientsfromcoreherbpairsexertmultitargetedandmulti-pathwayefectsformanagingobesityelated hypertension.

Keywordsbesityelatedhypertension;traditioalCinesemedicintreatment;datamning;etworkparmacolog;moleculadoing

高血压及其所导致的脑率中、缺血性心肌病等心血管疾病是全球负担最重的疾病[12]。（剩余11362字）