木姜叶柯叶的人血及入脑成分分析

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中图分类号R917 文献标志码A 文章编号 1001-0408（2026）07-0889-06

DOI 10.6039/j.issn.1001-0408.2026.07.11

AnalysisofcomponentsabsorbedintobloodandbrainofLithocarpuslitseifoliusleaves

LIU Huan’，YI Zirong1，HUANG Ting'，LIU Xiuhong1，YE Yunyao'，MA Yuming1，HU Mengqi，ZHANG Nan'， YANG Wenhao1，LIU Yang1，WANG Guopeng2[1. Schoolof Chinese Materia Medica，Beijing Universityof Chinese Medicine，Beijing 102488，China;2. Zhongcai Health（Beijing）Biological Technology Development Co.Ltd.，Beijing 101500，China]

ABSTRACTOBJECTIVEToanalyze the prototype components absorbed into bloodand brainofLithocarpuslitseifolius leaves， soas toprovideareferenceforclarifyingthepharmacological materialbasisof itspreventionandtreatmentofcentralnerous systemdiseases.METHODSTheethanolextractofL.litseifoliusleaves，aswellasthegastriclavagefluidandperfusionsolution wereprepared.Usingratsassubjects，plasmasamplesof intestinal wall metabolism，intestinal florametabolismandhepatic metabolismwerepreparedviainsituintestinalperfusionandclosed intestinallopmethod；whilecomprehensive metabolicplasma samples，braintissesamples，andcerebrospinalfluidsampleswerecolectedafterintragastricadministration.UPLC-HRMS technologywasutlizedtoanalyzeandidentifychemicalcomponentsandprototypecomponentsabsorbedintobloodandbrainof L ， litseifoliusleaves.RESULTSAtotalof66chemicalconstituentswereidentifiedinL.litseifoliusleaves，primarilyconsistingof flavonoids，organicacids，andothers.Atotalof16，13，11，and5prototypecomponents wereidentifiedinintestinal wal metabolism，intestinal florametabolism，hepaticmetabolism，andcomprehensivemetabolicplasmasamples，respectively. Additioall，4prototeomponentseredetectedinbraintisseand9incerebrospialfluidlorzin，rlbatinoinO -malonylhexoside，and phloretinwereidentifiedascommoncomponentsacross allsample types.CONCLUsIONsPrototype components absorbed into blood and brain of L .litseifolius leaves，such as phloridzin，trilobatin，phloretin，and other components may serve as the pharmacological material basis for their therapeutic efects on central nervous system diseases.

KEYWORDsLithocarpuslitseifoliusleaves；componentsabsorbed intoblood；componentsabsorbedintobrain；phloridzin;trilobatin； central nervous system diseases； UPLC-HRMS technology

木姜叶柯Lithocarpuslitseifolius（Hance）Chun为壳斗科柯属常绿乔木，其应用历史可追溯至南北朝时期[-2]。（剩余8910字）