《药物流行病学研究方法学指南（第2版）》及其系列解读（13）：系统评价与Meta分析的应用进展与案例

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【关键词】药物流行病学；方法学；指南；系统评价；Meta分析【中图分类号】 【文献标识码】A

【Abstract】As a pivotal study design in pharmacoepidemiology， systematic review and Metaanalysis could provide core evidence to support drug evaluations.The Guide on Methodological Standards in Pharmacoepidemiology （2nd edition） categorizes systematic review and Meta-analysis as two specific types of secondary research，outlines the application scenarios of Meta-analysis and network Meta-analysis in comparative drug efficacy research，and introduces the use of artificial inteligence in the literature screening phase of systematic review. Building upon the Guide （nd edition）， we further elaborate on the advances in the application of systematic review and Meta-analysis from three dimensions： the expansion of evaluation scope， innovations insynthesis methodology，and the transformation of intellgent paradigms.Finallytaking network Meta-analysis as anexample，we illustrate its implementation process inpharmacoepidemiological research.The objective of this article is to provide methodological references for researchers conducting systematic review and Meta-analysis in the field of pharmacoepidemiology.

【Keywords】Pharmacoepidemiology; Methodology; Guidelines; Systematic review; Meta-analysis

系统评价最早源于研究合成，旨在减少结果解释中的偏倚[]。（剩余34738字）